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In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes

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December 15, 2021

David R Snydman, Laura McDermott

Microbiol Spectr. 2021 Dec 22;9(3):e0190821. Epub 2021 Dec 15.
PMID: 34908432 | PMCID: PMC8672875 | DOI: 10.1128/Spectrum.01908-21

Abstract

Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We evaluated in vitro activity against 341 recent clinical isolates. The addition of avibactam to aztreonam had no effect on the anaerobic activity of aztreonam. IMPORTANCE This work shows that aztreonam-avibactam lacks activity against anaerobic organisms.