PhD | Director
Dr. Isberg has been an acknowledged leader in the field of bacterial pathogenesis for over 30 years, with particular emphasis on pneumonic and diarrheal diseases. He has a major interest in identifying strategies for eliminating drug resistance in nosocomial pathogens, focusing on Acinetobacter baumannii. Among his awards was election to the National Academy of Sciences in 2009.
Dr. Thorpe’s research includes translational work assessing the impact of antimicrobials on human gastrointestinal microbiota and metabolome, with a specific focus on treatment of C. difficile infection. She is interested in how microbial communities shift in response to disease and antibiotic treatments, and how those shifts may predispose to colonization with antibiotic resistant organisms or have other deleterious impacts. She is also interested in host-pathogen interactions with a particular focus on Shiga toxin-producing E. coli.
PhD | Associate Director & Combinatorial Treatment Core Director
Dr. Aldridge leads a multidisciplinary research group coupling quantitative single-cell measurements and mathematical modeling with the goal of shortening and simplifying treatment regimens against tuberculosis. The Aldridge Laboratory merges engineering and molecular approaches to develop quantitative descriptions of the determinants of mycobacterial stress tolerance and virulence.
PhD | Executive Director
Dr. Noonan is an experienced leader of interdisciplinary research teams both in academia and industry. He works closely with our faculty to develop grant proposals and is in charge of our outreach to pharma and philanthropy. His research interests include the discovery of vaccines and anti-microbial agents targeting important pathogens and the use of immunomodulatory biologics to control cytokine induction in sepsis.
MD, PhD | Senior Leadership
Dr. Leong is Edith Rieva and Hyman S. Trilling Professor and Chair of the Department of Molecular Biology and Microbiology at Tufts University School of Medicine. His research focuses on the interaction of pathogenic Escherichia coli, Borrelia burgdorferi (the Lyme disease spirochete) and Streptococcus pneumoniae with host immune and epithelial cells in order to understand the infectious process and develop novel therapies to prevent or treat these infections.
MD, FACP, FIDSA, FAST | Senior Leadership
Dr. Snydman has 35 years of experience in observational and interventional studies in translational research, including trials that resulted in FDA licensure of a biologic product. He has worked on epidemiologic aspects of antibiotic resistance for decades, focusing on hospital-acquired infections, anaerobes, C difficile, and MRSA. His current research is focused on the transmission of antibiotic resistance and C. difficile among nursing home patients and in health systems, as well as the impact of antimicrobial stewardship.
MD | In Memoriam
The name behind our center, Dr. Levy was a trailblazing force in the field of antimicrobial resistance. During his more than four decades at Tufts University and Tufts Medical Center, he led the paradigm shift in how we view antibiotic use and stewardship. In his work on mechanisms of antibiotic resistance and spread of resistance determinants among microbes, his was the first voice of warning of the dangers of antibiotic overuse in the emergence of drug resistance.
Associate Professor of Molecular Biology & Microbiology, TUSM
My group studies how Clostridioides difficile, a leading cause of antibiotic-associated diarrhea and gastroenteritis-associated death in the United States, forms infectious spores and how these spores germinate upon sensing specific bile salts in the mammalian gut. Spore formation and germination are essential for C. difficile to transmit disease, and analyses of these processes have revealed major differences relative to previously studied spore formers. We use a multi-disciplinary approach to identify regulators of these processes and elucidate their mechanisms of action. A better understanding of the basic biology of C. difficile sporulation and spore germination should facilitate the development of spore-specific therapies that can prevent C. difficile disease transmission. These analyses have also led us to study the mechanisms underlying antimicrobial resistance and responses to physiological stressors in C. difficile and develop methods for visualizing C. difficile’s response to these stressors.
Attending Physician in Geographic Medicine and Infectious Diseases, TMC; Associate Professor of Medicine, TUSM
I am an infectious diseases clincian and and an NIH-funded health disparities researcher. My research interests include prevention and treatment of infection diseases in people who use drugs and people who are incarcerated.
Assistant Professor of Pathology (Anatomy), TUCSVM
I investigate mechanisms by which we can use alternatives to antibiotics such as therapeutic vaccination and host-directed therapies to combat multi-drug resistant tuberculosis. My lab focuses on mycobacterial genetics to identify mycobacterial genes involved in virulence and evasion of the host-immune response, including vaccine responses. By studying TB virulence genes, I hope to identify TB antigens critical for TB survival in the host with the aim to target those TB proteins in vaccine design.
Clinical Assistant Professor, Emergency & Critical Care, TUCSVM
I study antimicrobial stewardship in dogs and cats, embracing One Health in my research. I collaborate with Tufts Medical Center’s Infection Control Team who work on several joint research projects to apply antimicrobial stewardship efforts used in human hospitals to companion animal medicine. I am also founder and co-chair of the Infection Control and Antimicrobial Stewardship Team (ICAST) at the Foster Hospital for Small Animals and Large Animal Hospital in Grafton.
Associate Professor of Biology, TUSAS; Co-Director of Science, Technology and Society
My lab has been using metagenomic sequencing to identify antibiotic resistance reservoirs in food systems, and we have also been working to identify how microbial interactions could drive the evolution of antibiotic resistance. More broadly, the research in my lab links ecological and evolutionary patterns in microbial communities with the molecular mechanisms that generate these patterns. Using tractable microbial communities from isolated from food systems, we have two broad research goals: identify the molecular mechanisms that control the assembly and function of microbial communities determine how microbial species evolve within multi-species communities. Our work will help develop principles of microbial community assembly that can guide the design and manipulation of microbial communities in agriculture, industry, medicine, and nature.
Associate Professor of Medical Education, TUSM; Director, Tufts University Center for Translational Science Education
Our work at CTSE engages future scientists and citizens in the science of health by fostering collaboration among biomedical scientists and high school educators. One of our projects focuses bring infectious diseases and AMR to high school classrooms across the country to increase science engagement and health literacy.
Research Assistant Professor of Medical Education, TUSM
My work bridges environmental surveillance with education through a unique tracking program that engages undergraduates and high school students in classroom-based research activities to monitor resistance levels in environmental samples worldwide. Data contributed by students is curated and recorded in a GIS-based mapping system, providing researchers with an overview of potential hotspots of antimicrobial resistance.
Vice Provost for Research, Tufts University; Arthur E Spiller Professor of Immunology, TUSM
My translational work has encompassed clinical studies evaluating immunological and microbiological responses following acute inflammatory diseases induced by sexually transmitted infections. Gonorrhea, caused Neisseria gonorrhoeae, is a disease of worldwide prevalence. The continued persistence and increased N. gonorrhoeae resistance to third generation cephalosporins is a warning for the development and spread of untreatable gonorrhea. One of our long-term goals is to develop a vaccine to treat sexually transmitted infections with emphasis on prevention of secondary complications in women.
Professor of Infectious Disease and Global Health, TUCSVM
My research focuses on the development and application of therapeutic biomolecules for treating a variety of diseases caused by pathogens such as C. difficile, Campylobacter, Vibrio cholera and various pathotypes of E. coli. Most of our therapeutic agents employ single domain antibody (sdAb) binding agents consisting of the VH region of heavy-chain-only Abs (VHHs) from immunized alpacas which have been selected for their ability to neutralize critical pathogen functions. These simple, stable VHH agents are then re-engineered in various ways to produce practical, cost-effective products with demonstrated potential to prevent or treat some diseases.
Assistant Professor of Small Animal Internal Medicine & Clinical Pharmacology, TUCSVM
I am a small-animal internist and clinical pharmacologist. I am part of a One Health collaboration with Annie Wayne, a veterinary criticalist at the Cummings School and fellow Levy CIMAR Core Faculty Member, as well as individuals at Tufts Medical Center. Together, we aim to bring human stewardship principles to companion animal veterinary medicine. I am also involved in clinical trials to provide evidence for appropriate antimicrobial treatment durations in veterinary patients.
Professor of Civil & Environmental Engineering, TUSE
The working title of the doctoral dissertation of Kate Woodward, P.E., who I advise is “Removal of Antibiotic Residues and Control of Antibiotics Movement from Cattle Industry Wastewater in Nebraska.” Antibiotics used in livestock production to treat and prevent infections may impact human health by promoting development and excretion of resistant bacteria or genes in animal manure.
Professor and Chair of the Division of Nutrition Data Sciences, TUFSN
Adjunct Professor of Civil and Environmental Engineering, TUSE; Public Health & Family Medicine, TUSM, Mathematics, TUSAS
Emerging and re-emerging diseases, environmental epidemiology, molecular biology, nutrition, and growth
Frank C. Doble Professor of Biomedical Engineering; Dean of Research, TUSE
My research interests are in the convergence of technology, biologically inspired materials, and the natural sciences with an emphasis on new transformative approaches for sustainable materials for high-technology applications.
Attending Physician, TMC; Assistant Professor, TUSM
I am the Associate Director for the Antimicrobial Stewardship Program at Tufts Medical Center. My areas of interest are antimicrobial stewardship in long-term care facilities (LTCFs), hospital-acquired infections, diagnostic stewardship and rapid diagnostics in infectious diseases as well as continuing partnerships with public health authorities in order to tackle antimicrobial resistance.
Assistant Professor of Pathology, TUCSVM
We have two main interests relevant to antimicrobial resistance. Our newest is using the Diversity Outbred mouse population to test combinations of antibiotics for efficacy against Mycobacterium tuberculosis the bacterium that causes tuberculosis. The second is how bone marrow mesenchymal stem cells protect M. tuberculosis from antibiotics and host immunity. To study this phenomenon we use a combination of in vitro and in vivo methods.
Interim Dean, TUSM; Chief Academic Officer for Wellforce, TMC
My clinical interests include infections in immunocompromised patients and S. aureus infections, and my research interests focus on S. aureus and the development of new anti-infective agents. (Note: Dr. Boucher was Director of the Levy CIMAR along with Dr. Ralph Isberg from 2018-2021. Her work in antimicrobial resistance extends to education, policy, outreach, and more. She is a Fellow and Member of the Board of Directors of the Infectious Diseases Society of America, and is appointed to the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria, or PACCARB.)
Professor of Molecular Biology & Microbiology, TUSM
My lab investigates factors required for Klebsiella pneumoniae to cause disease in lungs, blood, liver and bladder, as well as genetic, host-derived, and chemical factors that render multi-drug resistant Klebsiella more susceptible to treatment.
Professor of Infectious Disease and Global Health, TUCSVM
My lab seeks to understand genetic factors that impact susceptibility to infectious disease, specific or general and the repercussions for potential epidemics, persistence, and evolution of those infectious agents. Using a combination of our own field samples, collaborations and published genomic data, we are developing tools to investigate correlates of influenza disease resistance and/or susceptibility among multiple species. We seek to provide unbiased host factors associated with viral resistance/susceptibility while contributing valuable tools for all investigators.
Professor & Director, Tufts Center for the Study of Drug Development
My group studies the economic, political, technical and scientific challenges of developing new antimicrobials and other pharmaceutical products. We also examine how regulatory policy influences innovation in areas of unmet medical need, such as AMR.
I am interested in the molecular design of structural scaffolds for discovering new antimicrobial compounds especially those against resistant organisms, as well as the use of organic chemistry, biological chemistry, biophysics, and cellular biology to understand mechanism of action of therapeutically relevant antibiotics.
Dean Ad Interim and Karol Family Professor of Chemical and Biological Engineering; Tissue and Metabolic Engineering Laboratory, TUSE
My research interests include metabolic engineering, tissue engineering, and systems biology, as well as the study of cellular metabolism and its role in shaping biological function. A major ongoing effort is to investigate metabolites that mediate chemical communication between bacterial gut microbiota and the host.
Senior Clinical Pharmacy Specialist in Infectious Diseases, TMC
I am the senior pharmacist responsible for antimicrobial stewardship and ID consult services Tufts Medical Center. I serve as a preceptor and lecturer for pharmacy residents and ID fellows. My research interests include clinical and economic outcomes associated with antimicrobial stewardship.
Research Assistant Professor of Civil & Environmental Engineering, TUSE
I use genomic and epidemiological approaches to understand how exposures to food, animals, and the environment can impact human colonization and infection with antibiotic-resistant bacteria, particularly in low-resource settings. Currently, I am exploring whether nutritional or behavioral interventions could improve young children’s gut colonization resilience against resistant pathogens.
Attending Physician, TMC;
Assistant Professor, TUSM
I study HIV drug resistance and translate results into public health and antiretroviral therapy program policy in low- and middle-income countries. In addition, my laboratory studies inter- and intra-host diversity of SARS-CoV-2 and SARS-CoV-2 antiviral drug resistance.
Assistant Professor of Molecular Biology & Microbiology, TUSM
My lab’s research centers on understanding how Mycobacterium tuberculosis exploits environmental cues to survive and grow in its host. As part of this focus, we seek to (i) elucidate regulatory nodes that enable the bacterium’s coordinated response to disparate cues and that thus represent novel therapeutic targets in both drug-sensitive and drug-resistant bacteria, and (ii) understand how microenvironment heterogeneity impacts infection outcome and treatment efficacy.
Associate Professor of Medicine, TUSM; Attending Physician, TMC
I investigate the risk factors for infections by antibiotic-resistant organisms and develop scores to target certain patients for therapy for such organisms. My research focuses on infections by resistant Gram negative pathogens, C. difficile, and other hospital-acquired pathogens.
Our lab studies environmental and zoonotic transmission of antibiotic resistance, primarily in low-income countries, with an aim to develop strategies to prevent early life exposure to antibiotic resistant pathogens. I serve as the Blum Center for Developing Economies Distinguished Chair in Global Poverty and Practice at Berkeley.
My laboratory focuses on understanding host-pathogen interactions, with emphasis on respiratory pathogens, using this knowledge to develop novel preventive and therapeutic strategies to protect against bacterial infection. Our work focuses on both the factors used by bacteria to establish colonization and cause disease and how this is counteracted by the host inflammatory response to colonization and infection. We are working on several major research projects, including the study of the direct bactericidal activity of a human milk protein-lipid complex against various bacterial species as well as its adjuvant activity in sensitizing bacteria to a broad range of common antibiotics to provide novel therapeutic strategies against respiratory and other infections with antibiotic-resistant bacteria.
Our lab investigates the molecular basis of antibiotic resistance and disease development in infections with hospital-acquired pathogens. Our primary focus is the troublesome microbe Acinetobacter baumannii, a frequent cause of pneumonia and sepsis in intensive care units that has developed resistance to virtually all clinically useful antibiotics. We examine unique strategies used by the pathogen to build and fortify its cell envelope, including regulatory networks hardwired to amplify resistance and virulence upon detection of antimicrobial stress. We employ a variety of tools ranging from systems biology and molecular genetics to animal models of infection. Long-term, we will exploit these strategies as targets for novel therapies against nosocomial diseases.
Our lab’s research in the global health arena focuses on antimicrobial resistance, One Health integrated solutions and improved testing of drug quality in relations of health equity and antimicrobial resistance. Our work in the lab works closely with work in the field and in the policy domain for rich understanding and efficient implementation. Recent work has also focused on access to better healthcare for refugees and marginalized populations and the role engineers can play in improving the health of the most vulnerable people. Our students come from not just engineering but also public health, social sciences and humanities to collectively address some of the most pressing global problems in access to health and health equity. We are also interested in issues of science literacy and broader engagement of the public. My recent book, “Biography of Resistance,” is an effort in that direction.
Our lab focuses on the development and application of experimental and computational Systems Biology tools to study infectious diseases as complete systems while in interaction with their environment (e.g. the host and/or drugs). Our ultimate goal is to develop approaches to predict and detect the emergence of (drug-resistant) infectious diseases and strategies to eradicate them. To achieve this, we employ a unique mixture of approaches from the fields of Biology, Chemistry, Physics and Computer Science, including a variety of sequencing strategies, microfluidics, robotic automation, immune system monitoring, in vivo disease models, computational modeling and machine learning.