Feugiat nulla facilisis at vero eros et curt accumsan et iusto odio dignissim qui blandit praesent luptatum zzril.
+ (123) 1800-453-1546

Related Posts

Epidemiologic Trends in Clostridioides difficile Isolate Ribotypes in United States from 2011 to 2016

May 6, 2020

Snydman DR, McDermott LA, Jenkins SG, Goldstein EJG, Patel R, Forbes B, Johnson S, Gerding DN, Thorpe CM,  Walk ST

Anaerobe. 2020 Jun;63:102185.  Epub 2020 May 6.
PMID: 32387171 | DOI: 10.1016/j.anaerobe.2020.102185


Geographic and temporal trends in the distribution of PCR ribotypes for Clostridioides difficile associated diarrheal isolates obtained in the United States (US) are changing. As part of a US national surveillance program of C. difficile susceptibility to fidaxomicin, we quantified the distribution of PCR ribotypes of stool isolates collected from 2011 to 2016.

C. difficile isolates or C. difficile toxin + stools from patients with C. difficile infection (CDI) were submitted for testing to Tufts Medical Center from 6 geographically distinct medical centers. Following isolation and confirmation as C. difficile, approximately 35% of the isolates were randomly sampled, stratified by center, for PCR ribotyping by capillary gel electrophoresis. Toxin gene profiling was performed on all isolates.

939 isolates from a total of 2814 (33.4%) isolated over the 6 years were analyzed. Seventy unique ribotypes were observed, including 19 ribotypes observed 10 or more times. Sixteen ribotypes were not previously observed in our data base. Ribotype 027 declined by more than 60% over the 6 years of the survey from 35.3% to 13.1% (p < 0.001). Ribotype 106 was the most common in 2016, followed by 027 and 014–020. There were strong correlations between 027 and binary toxin with the 18 base pair deletion of tcdC and ribotype 078–126 had 100% concordance with the previously described tcdC 39 base pair deletion.

The frequency of ribotypes in the US has changed with a marked decline in 027. Each of the geographical areas had variations which differed from each other, but collectively, these results suggest that the changing epidemiology of C. difficile in the US is consistent with what is being seen in Europe. Continued surveillance and monitoring of changes in ribotype distributions of C. difficile are warranted.


Source: https://www.sciencedirect.com/science/article/pii/S107599642030041X?via%3Dihub